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MT1A linear synthetic analog of α-MSH researched for melanogenesis and photoprotection without the sexual side effects of Melanotan II.
Melanotan I (Afamelanotide) is a linear synthetic analog of α-melanocyte-stimulating hormone (α-MSH). It binds primarily to MC1R on melanocytes, stimulating melanin production without the sexual arousal effects associated with Melanotan II's MC4R activity. It has received regulatory approval in Europe for erythropoietic protoporphyria (EPP) and is researched for photoprotection and UV-independent tanning.